基礎薬学講座 生物物理化学部門
講座紹介
薬品物理化学教室は、本学部開設の翌年1965年7月に追加設置され、初代教室主任の松村教授は糖質化学を研究され、1992年3月に退任。1992年10月に中村が長岡技術科学大学より着任しました。
東京大学薬学部や前任大学におけるのと同様に、生体高分子（特にタンパク質）の立体構造をX線結晶構造解析法により明らかにする研究を行っております。
東京大学薬学部や前任大学におけるのと同様に、生体高分子（特にタンパク質）の立体構造をX線結晶構造解析法により明らかにする研究を行っております。
講座員
教員（専任）
| 役職 | 氏名 | name |
|---|---|---|
| 教授 | 合田 浩明 | Gouda Hiroaki |
| 助教 | 渡邉 友里江 | Watanabe Yurie |
| 助教 | 早川 大地 | Hayakawa Daichi |
研究業績
すべて開く ＋
2006年業績
生体高分子の構造解析
Crystallization and Preliminary X-Ray Crystallographic Analysis of Yeast Tyrosyl-tRNA Syntheses Complexed with Its Cognate tRNA Kusakabe Y., Ohno S., Tnaka N., Nakamura M., Tsunoda M., Moriguchi T., Asai N., Sekine M., Yokogawa T., Nishikawa K. & Nakamura K.T. Protein Peptide Lett. 13, 417-419 (2006).Crystal Structures of Mouse Autocrine Motility Factor in Complkex with Carbohydrate Phosphate inhibitors Provide Insight into Structure-Activity Relationship of the Inhibitors Tanaka N., Haga A., Naba N., Shiraiwa K., Kusakabe Y., Hashimoto K., Funasaka T., Nagase H., Raz A.& Nakamura K.T. J. Mol. Biol. 356, 312-324 (2006).
The Autocrine Motility Factor (AMF) and AMF-receptor Combination Needs Sugar Chain Recognition Ability and Interaction Usingthe C-terminal Region of AMF Haga A., Tanaka N., Funasaka T., Hashimoto K., Nakamura K.T., Watanabe H., Raz A. & Nagase H. J. Mol. Biol. 358, 741-753 (2006).
2005年業績
生体高分子の構造解析
Functional Characterization of 2',5'-Linked Oligoadenylate Binding Determinant of Human RNase L Nakanishi M., Tanaka N., Mizutani Y., Mochizuki M., Ueno Y., Nakamura K.T. & Kitade Y.J. Biol. Chem. 280, 41694-41699 (2005)Molecular basis for recognition of 2',5'-linked oligoadenylates by the N-terminal ankyrin repeat domain of human ribonuclease L Tanaka, N., Nakanishi, M., Kusakabe, Y., K., Goto Y., Kitade, Y., & Nakamura, K.T. Nucleic Acids Symp. Ser. 49, 323-324 (2005).
Mutational analyses of Plasmodium falciparum and human S-adenosylhomocysteine hydrolases Nakanishi M., Yabe S., Tanaka N., Ito Y., Nakamura K.T. & Kitade Y. Mol Biochem Parasitol 143, 146-151 (2005)
Crystallization of the N-Terminal Ankyrin Repeat Domain of the 2-5A-Dependent Endoribonuclease, RNase L Tanaka N., Nakanishi M., Kusakabe Y., Goto Y., Kitade Y. & Nakamura K.T. Protein Peptide Lett. 12, 387-389 (2005).
2004年業績
生体高分子の構造解析
Crystal structure of creatininase reveal the substrate-binding site and provide an insight into the catalytic mechanism Yoshimoto, T., Tanaka, N., Kanada, N., Inoue, T., Haratake, M., Nakamura, K.T., Yue, X., & Ito, K. J. Mol. Biol. 337, 399-416 (2004).Crystallization and preliminary X-ray crystallographic analysis of Plasmodium falciparum S-adenosyl-L-homocycteine hydrolase Tanaka, N., Kusakabe, Y., Shiraiwa, K., Sakamoto, Y., Nakanishi, M., Kitade, Y., & Nakamura, K.T. Protein Peptide Lett. 11, 201-205 (2004).
Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum. Tanaka, N., Nakanishi, M., Kusakabe, Y., Shiraiwa, K., Yabe, S., Ito, Y., Kitade, Y., & Nakamura, K.T. J. Mol. Biol. 343, 1007-1017 (2004).
Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L. Tanaka, N., Nakanishi, M., Kusakabe, Y., Goto, Y., Kitade, Y., & Nakamura, K.T. EMBO J. 23, 3929-3938 (2004).
Crystallization and preliminary X-ray crystallographic studies of mouse autocrine motility factor. Naba, N., Tanaka, N., Shiraiwa, K., Kusakabe, Y., Funasaka, T., Haga, A., Nagase, H., Raz, A., & Nakamura, K.T. Acta Crystallogr. Section D60, 2084-2086 (2004).
Crystallization and preliminary X-ray crystallographic studies of human 2‘,3’-cyclic-nucleotide 3'-phosphodiesterase. Sakamoto, Y., Tanaka, N., Ichimiya, T., Kurihara, T., & Nakamura, K.T. Acta Crystallogr. Section D60, 2095-2097 (2004).
Three-dimensional structure of the ternary complex of yeast tyrosyl-tRNA synthetase. Tsunoda, M., Kusakabe, Y., Tanaka, N., Ohno, S., Nakamura, M., Senda, T., Sekine, M., Yokogawa, T., Nishikawa, K., & Nakamura, K.T. Nucleic Acids Symp. Ser. 48, 155-156 (2004).
Three-dimensional structure of a cyclic-nucleotide phosphodiesterase from human brain. Sakamoto, Y., Tanaka, N., Ichimiya, T., Kurihara, T., & Nakamura, K.T. Nucleic Acids Symp. Ser. 48, 157-158 (2004).
Three-dimensional structure of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum. Tanaka, N., Nakanishi, M., Kusakabe, Y., Shiraiwa, K., Yabe, S., Ito, Y., Kitade, Y., & Nakamura, K.T. Nucleic Acids Symp. Ser. 48, 281-282 (2004).
Structural study of the archaeal homologous recombinant protein complexed with DNA fragments C. Naoe, M. Tsunoda and K.T. Nakamura Nucleic Acids Symposium Series, 48:115-116.2004
Structural significances of pseudouridination and methylation of uridine residues in tRNA: X-ray analyses of DNA dodecamers containing uridine and pseudouridine I. Koike, S. Naito, W. Adachi, M. Tsunoda, A. Ono and A. Takenaka Nucleic Acids Symposium Series, 48:253-254.2004
その他
Schiff base formation between 5-formyl-2’-deoxy-uridine and lysineε-amino group at monomer and oligomer levels A. Kittaka, C. Horii, H. Tanaka, T. Miyasaka, K.T. Nakamura, R. Kuroda, and T. Sugiyama Heterocycles, 64, 367-382(2004).Crystal structure of 1,10-dibromodecane and its infrared intensity in a urea clathrate and in the crystal Isao Kanesaka, Sachie Matsuzawa, Ysutomu Ishioka, Yasuyuki Kitagawa, Keiichi Ohno Spectrochimica Acta, A60, 2621-2626(2004).